Items plugged into this laptop are/were:

+ a Logitech VX Revolution (Wireless) Mouse.

+ a Logitech diNovo Edge Keyboard (also wireless).

+ a USB cable into my USB KVM which also shows up as a mouse/HID device

+ a Bluetooth presentation mouse, though not currently active.

I did the normal trouble shooting steps.   Made sure my anti-viri software was up-to-date. Plugging and unplugging mice and keyboards.  I *thought* it was the diNovo Edge as it also has a little track pad.   It would go away for a while but not permanently.

It made using the computer almost impossible.

After a little more research I found technet Article: The Microsoft mouse pointer moves erratically or does not respond when you use a Microsoft pointing device # Q321122 and was appalled at the 82 steps it took to fix this.   Why this is still an issue after almost 2 years, and why since it is an issue that there isn’t a utility to deal with the 2000 registry entries I had to manually delete is beyond me.

But if your mouse suddenly gets the shakes.  You may want to look into this.

FWIW, deleting all the devices from the device manager had a greater impact than deleting all the registry entries.

-Datapoohbah.

No offense was intended to those that actually have Parkinsons disease and shake like my mouse was shaking.  It would be nice if you could eliminate a few drivers and registry entries to get rid of it.